I aim to understand the dynamics of protein folding under force, and its implications for biological systems.
I build single molecule instruments:
--the folding/unfolding dynamics of Titin, and its role in muscle contraction and elasticity.
-- the mechanical architecture of the Pili of gram positive pathogens.
--mechano-sensing by Talin domains
Arthur Schopenhauer: "The truth can wait, for it lives a long life"
Karl Popper: "The growth of knowledge depends entirely upon disagreement"
Thomas Kuhn: "Science undergoes periodic paradigm shifts"
I work at the interface between physics and biology, aiming to understand quantitively how proteins work under mechanical force.
- How do protein ligands bind to molecular substrates under force?
- How do proteins respond to arbitrary force signals?
- How do proteins fold under force at very short timescales?
I study the mechanical properties of the proteins used by pathogenic bacteria to adhere to tissues.
- Mechanical properties of the Gram positive pilus proteins.
- Mechano-chemical modulation of bacterial adhesin proteins.
- Force and chemical disruption of the pathogenic adhesion.
- Molecular binding to protein substrates under force.
I am in charge of the molecular biology section of the laboratory.
- Genetic engineering.
- Cell culture.
- Protein expression and purification.
- Mechanical antibiotics against Gram positive pathogens.
Columbia Presbiteryan Hospital, New York, U.S.
Postdoctoral Researcher (2016-2018)
Assistant Professor in Ashoka University, New Delhi, India
Postdoctoral Researcher (2012-2018)
Assistant Professor in Universidad de Santiago, Santiago, Chile
Pediatrics Residency at Boston Children's Hospital, Harvard Medical School, U.S.
Postdoctoral Researcher (2013-2017)
Postdoctoral Researcher at Ecole Normale Superieure, Paris, France
Postdoctoral Researcher (2010-2015)
Assistant Professor at University of Wisconsin-Milwaukee, U.S.
Postdoctoral Researcher (2008-2014)
Assistant Professor/Group Leader at National Institute of Cardiovascular Research (CNIC), Madrid, Spain
Postdoctoral Researcher at Department of Chemistry & Chemical Biology, Harvard University, U.S.
Postdoctoral Researcher (2010-2013)
Principal Investigator in Chemical Engineering, Ben-Gurion University, Israel
Postdoctoral Researcher (2005-2013)
Group Leader at Nanogune, San Sebastian, Spain
Postdoctoral Researcher (2005-2012)
Professor in Physics, Kings College London, U.K.
Assistant Professor at School of Medicine, UCSF, U.S.
Podtdoctoral Researcher (2003-2007)
Associate Professor in Chemical Sciences, Tata Institute of Fundamental Research, India
Postdoctoral Researcher (2004-2007)
Associate Professor in Physics, New York University, U.S.
Postdoctoral Researcher (2006-2007)
Professor at Heidelberg Institute for Theoretical Studies, Germany
Postdoctoral Researcher (2007-2008)
Associate Professor at University of Warsaw, Poland
Postdoctoral Researcher (1999-2004)
Professor at Department of Chemistry, The University of British Columbia, Canada
Postdoctoral Researcher (1993-2002)
Professor at Duke University, U.S.
Postdoctoral Researcher (1989-1992, 1994-2002)
Professor at UTMB, U.S.
Postdoctoral Researcher (1987-1992)
Professor at University of Seville, Spain
Postdoctoral Researcher (1994-2003)
Laboratory Director at Instituto Cajal, Madrid, Spain